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Alpha-thalassemia - myelodysplastic syndrome
1 OMIM reference -
1 associated gene
12 signs/symptoms
PROTEIN INTERACTIONS: 1
Acute promyelocytic leukemia
1 OMIM reference -
7 associated genes
No signs/symptoms info
Alpha-thalassemia - myelodysplastic syndrome
Acute promyelocytic leukemia

ATRX
(UniProt - OMIM)
 NABP1
(UniProt - OMIM)
NPM1
(UniProt - OMIM)
NUMA1
(UniProt - OMIM)
PML
(UniProt - OMIM)
RARA
(UniProt - OMIM)
STAT5B
(UniProt - OMIM)
ZBTB16
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
ATRX
(0.65)
PML


Citations in the biomedical literature:


Alpha-thalassemia - myelodysplastic syndrome
ATRX
Acute promyelocytic leukemia
NABP1 NPM1 NUMA1 PML RARA STAT5B
ZBTB16



Alpha-thalassemia - myelodysplastic syndrome
Acute promyelocytic leukemia

Synonym(s):
- ATMDS
- Acquired HbH disease
- Acquired hemoglobin H disease
Synonym(s):
- Acute myeloblastic leukemia type 3
- Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
Classification (Orphanet):
- Rare genetic disease
- Rare hematologic disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -
Classification (ICD10):
- Neoplasms -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: adulthood
Average age of death: elderly
Type of inheritance: sporadic
Epidemiological data:
(no data available)
External references:
1 OMIM reference -
No MeSH references
External references:
1 OMIM reference -
1 MeSH reference: D015473
Alpha-thalassemia - myelodysplastic syndrome

Very frequent
- Asthenia / fatigue / weakness
- Microcytic anemia
- Myelodysplastic syndrome
- Polynuclear cells / neutrophils anomalies / neutropenia
- Thrombocytopenia / thrombopenia

Frequent
- Bruisability
- Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction

Occasional
- Acute leukemia
- Immunodeficiency / increased susceptibility to infections / recurrent infections
- Neoplasms / tumors
- Splenomegaly


Acute promyelocytic leukemia

(no data available)